Obama health care plan - HEALTH, BEAUTY & FITNESS

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Little royal riding hood: Queen Elizabeth goes for a spin

By Rina Raphael

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Photos showing Queen Elizabeth wearing her hoodie while driving her Range Rover are going viral, and even though she barely clears the steering wheel, she looks pretty tough. TODAY's Natalie Morales reports.

Is it a hoodie? (Unlikely.) A pinned-back scarf? Maybe a Jedi cloak?

Never underestimate the fashion skills of Queen Elizabeth, who was spotted in a still-unidentified hair covering while taking a Range Rover for a spin at her Balmoral estate in England. Chauffeur? Not for this royal grandma, who barely reached the steering wheel as she channeled a Grace Kelly look. All together now: awww.

TODAY

Fashion-forward monarch: Queen Elizabeth II is seen wearing a chic head-covering while driving a Range Rover at Balmoral Castle, England.

While we likely won't see Her Majesty taking as many fashion risks as the bikini-clad Duchess of Alba, 86, we still appreciate the queen?s bold style. Take a look at a few favorites:

Getty Images

From unique prints to fabulous hats, the British monarch's fashion choices often show a sense of fun. Take a look through Queen Elizabeth II's signature looks over the years.

Rina Raphael is a TODAY.com editor who is still waiting for the queen to go ombre.

More from TODAY Style:
Beauty secrets from an 80-year-old ?goddess? of style
Happy 65th birthday, Camilla, Duchess of Cornwall!
Two hats rented by Duchess Kate sell for a whopping $10,836

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Cyborg tissue is half living cells, half electronics

They beat like real heart cells, but the rat cardiomyocytes in a dish at Harvard University are different in one crucial way. Snaking through them are wires and transistors that spy on each cell's electrical impulses. In future, the wires might control their behaviour too.

Versions of this souped-up, "cyborg" tissue have been created for neurons, muscle and blood vessels. They could be used to test drugs or as the basis for biological versions of existing implants such as pacemakers. If signals can also be sent to the cells, cyborg tissue could be used in prosthetics or to create tiny robots.

"It allows one to effectively blur the boundary between electronic, inorganic systems and organic, biological ones," says Charles Lieber, who leads the team behind the cyborg tissue.

Artificial tissue can already be grown on three-dimensional scaffolds made of biological materials that are not electrically active. And electrical components have been added to cultured tissue before, but not integrated into its structure, so they were only able to glean information from the surface.

Electrically inflamed

Lieber's team combined these strands of work to create electrically active scaffolds. They created 3D networks of conductive nanowires studded with silicon sensors. Crucially, the wires had to be flexible and extremely small, to avoid impeding the growth of tissue. The scaffold also contained traditional biological materials such as collagen.

The researchers were able to grow rat neurons, heart cells and muscle in these hybrid meshes. In the case of the heart cells, they started to contract just like normal cells, and the researchers used the network to read out the rate of the beats.

When they added a drug that stimulates heart cell contraction, they detected an increase in the rate, indicating the tissue was behaving like normal and that the network could sense such changes.

Lieber's team also managed to grow an entire blood vessel about 1.5 centimetres long from human cells, with wires snaking through it. By recording electrical signals from inside and outside the vessel? something that was never possible before? the team was able to detect electrical patterns that they say could give clues to inflammation, whether tissue has undergone changes that make it prone to tumour formation or suggest impending heart disease.

Commanding cells

"You could use these things to directly measure the effects of drugs in synthetically grown human tissue without ever having to test them in an actual human being," says Lieber's colleague Daniel Kohane. He also envisions tissue patches that could be added to the surface of a heart, say, to monitor for problems.

Vladimir Parpura, a neurobiologist at the University of Alabama, Birmingham, who was not involved in the study, suggests using the tissue to build tiny, biomimetic robots or implants that repair damaged tissue via electronic pulses.

So far, though, the researchers have only used the electrical scaffolds to record signals? they have yet to feed commands to cells. So Lieber's next step is to add components to the nanoscaffold that could "talk" to neurons. He says the goal is to "wire up tissue and communicate with it in the same way a biological system does".

Journal reference: Nature Materials, DOI: 10.1038/nmat3404

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Compound discovered that boosts effect of vaccines against HIV and flu

Monday, August 27, 2012

Oxford University scientists have discovered a compound that greatly boosts the effect of vaccines against viruses like flu, HIV and herpes in mice.

An 'adjuvant' is a substance added to a vaccine to enhance the immune response and offer better protection against infection.

The Oxford University team, along with Swedish and US colleagues, have shown that a type of polymer called polyethyleneimine (PEI) is a potent adjuvant for test vaccines against HIV, flu and herpes when given in mice.

The researchers were part-funded by the UK Medical Research Council and report their findings in the journal Nature Biotechnology.

Mice given a single dose of a flu vaccine including PEI via a nasal droplet were completely protected against a lethal dose of flu. This was a marked improvement over mice given the flu vaccine without an adjuvant or in formulations with other adjuvants.

The Oxford researchers now intend to test the PEI adjuvant in ferrets, a better animal model for studying flu. They also want to understand how long the protection lasts for. It is likely to be a couple of years before a flu vaccine using the adjuvant could be tested in clinical trials in humans, the researchers say.

'Gaining complete protection against flu from just one immunisation is pretty unheard of, even in a study in mice,' says Professor Quentin Sattentau of the Dunn School of Pathology at Oxford University, who led the work. 'This gives us confidence that PEI has the potential to be a potent adjuvant for vaccines against viruses like flu or HIV, though there are many steps ahead if it is ever to be used in humans.'

HIV, flu and herpes are some of the most difficult targets to develop vaccines against. HIV and flu viruses are able to change and evolve to escape immune responses stimulated by vaccines. There aren't any effective vaccines against HIV and herpes as yet, and the flu vaccine needs reformulating each year and doesn't offer complete protection to everyone who receives it. Finding better adjuvants could help in developing more effective vaccines against these diseases.

Most vaccines include an adjuvant. The main ingredient of the vaccine ? whether it is a dead or disabled pathogen, or just a part of the virus or bacteria causing the disease ? primes the body's immune system so it knows what to attack in case of infection. But the adjuvant is needed as well to stimulate this process.

While the need for adjuvants in vaccines has been recognised for nearly 100 years, the way adjuvants work has only recently been understood. The result has been that only a small set of adjuvants is used in current vaccines, often for historical reasons.

The most common adjuvant by far is alum, an aluminium-containing compound that has been given in many different vaccines worldwide for decades. However, alum is not the most potent adjuvant for many vaccine designs.

'There is a need to develop new adjuvants to get the most appropriate immune response from vaccines,' says Professor Sattentau, who is also a James Martin Senior Fellow at the Oxford Martin School, University of Oxford.

The Oxford University team found that PEI, a standard polymer often used in genetic and cell biology, has strong adjuvant activity.

When included in a vaccine with a protein from HIV, flu or herpes virus, mice subsequently mounted a strong immune response against that virus. The immune response was stronger than with other adjuvants that are currently being investigated.

The team also showed that PEI is a potent adjuvant in rabbits, showing the effect is not just specific to mice and could be general.

Another potential advantage of PEI is that it works well as an adjuvant for 'mucosal vaccines'. These vaccines are taken up the nose or in the mouth and absorbed through the mucus-lined tissues there, getting rid of any pain and anxiety from a needle. Mucosal vaccines may also be better in some ways as mucosal tissues are the sites of infection for these diseases (airways for respiratory diseases, genital mucosa for HIV and herpes).

Professor Sattentau suggests that: 'In the best of all possible worlds, you could imagine people would have one dose of flu vaccine that they'd just sniff up their nose or put under their tongue. And that would be it: no injections and they'd be protected from flu for a number of years.

'It's just a vision for the future at the moment, but this promising adjuvant suggests it is a vision that is at least possible.'

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University of Oxford: http://www.ox.ac.uk/

Thanks to University of Oxford for this article.

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Indonesia's e-commerce market only 0.7% (USD 0.9B) of total retail ...

A new report by DailySocial Research on the e-commerce market in Indonesia has revealed, among other things, that the country?s e-commerce market is a drop in the ocean compared to total retail sales, at only 0.7% (USD0.9 billion) out of USD134 billion.

The research project is a collaboration with Veritrans, an online payment processor for the Indonesian market. The team collected data through first-hand interviews, existing information on the Internet, and transaction information from e-commerce companies in Indonesia, which includes Kaskus, the country?s leading online classified ads site. Online shoppers. 584 of them, were surveyed as well.

The report is available as a free download on the DailySocial website.

For this project, DailySocial has defined e-commerce as ?the sales of goods and services where an order is placed by the buyer or price and terms of sale are negotiated over the Internet.?

The report adds that ?payment does not necessarily need to be made online,? and can include classified ads sites. Online travel services, financial brokers and dealers, and ticket sales agencies do not count, however.

More findings from the report:

• Average annual e-commerce spend per e-commerce user is USD 256, lower than Brazil (USD 824), China (USD 799), and United States (USD 1,111).
• Percentage of e-commerce users out of the internet population is 6.5%, again lower than Brazil (17%), China (28%), and US (71%).
• More than 2/3 of e-commerce users access the Internet via desktops or laptops at home.
• More than a quarter of users spend over 30 hours per week online.
• Search and social networking are the most popular applications of the Internet for e-commerce users, with many Indonesian businesses engaging potential customers through these channels.
• Fashion items are the most popular goods bought online, followed by travel bookings and music/video/games. More popular categories in developed markets, like grocery shopping, are non-existent.
• Half of online shoppers use Kaskus or Facebook to shop.
• Bank transfer remains the most popular mode of e-commerce payment, despite the fact that they require double the number of steps compared to credit card payment. Online payment solutions are still fragmented and not widely used.
• Majority of online shoppers spend up to USD 55 per online transaction.
• The e-commerce market could grow ten-fold to USD10 billion by 2015, driven by strong economic growth and rising purchasing power.
• Slow internet and unreliable delivery time, poor product quality and customer service, as well as the lack of online transaction facilities are key obstacles to explosive growth in e-commerce.

About The Author

Terence LEE - Assistant Editor

Terence is an online media nut that is obsessed with writing and publishing for the Internet. Recently, he took up photography to expand his repertoire, and hopes to learn videography soon. He has worked in both online and print publications such as The Straits Times, Today, Mind Your Body, The Online Citizen, and Funkygrad. In 2010, he co-founded New Nation, a current affairs online magazine for young adults with a couple of like-minded folks. Terence can be found on LinkedIn and Twitter.

Read other posts by Terence LEE here.

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Losing A Friend ? madeinaccra

August 27, 2012 ?

I lost my best friend in Ghana this past week. It?s really humbling and jarring to find you?ll no longer have this person in your life again. I have yet to experience what it?s like to lose a loved one (in death) so close to you, so forgive me for even the mere consideration, but I wonder if losing a friend and knowing he/she is alive and well but completely inaccessible forever is worse than the reality about a dearly departed. I?m a bit numb about it all. I keep looking down at the keyboard because I can?t feel the keystrokes. This is a lil? departure from what I usually pontificate about my life in Ghana, but sitting in bed starring out into the darkness of the room with an endless stream of disjointed thoughts none of which explains my reality isn?t any helpful, so it?s back to the safety of my diary.

I made a terrible and very regrettable mistake. It won?t help making this a heaping confession for your eyes or to feed our natural penchant for the juicy details about the dark and normally inaccessible crevasses of other people?s lives, so I won?t go there. But I did lose a great friend, a new friendship, and a relationship I always imagined will meld so well with the long-standing ones of best friends and immediate family. I know I?m being vague, but this is as much as I can muster for even a diary (and one that?s not so private), so bear with me.

What I?m struggling with? or at least one of the things I?m struggling with is how we can so easily lose our way even when our intuition and every single cell of our being rings warning bells. I?ve always prided myself in being level-headed, having what I imagined as a fairly resolute moral compass (which sometimes doubled as a platform from which to judge those flaw and corrupted), and being very considerate about others? feelings often to points where I?m left vulnerable and open to being hurt. But today, somehow a few innocuous words and very regrettable missteps ended a friendship. I know?vague, but plug in your own variables in your own imaginative way (but don?t be so quick to render judgment) and apply whatever scenarios you come up with to fit my misery.

Two weeks ago, I was confronted with what initially seemed an innocent problem; a cute and yet embarrassing confessional by my friend at the end of a drunken stupor. As flattering as this confession was, it seemed completely out of character for this person, something neither of us ever expected to hear, and one I was quick to passively dismiss as yet another reason people shouldn?t drink. That was the end of that from my perspective that night. Yet, it really wasn?t, and instead of confronting it head-on and giving it a quiet end, I consciously acknowledged its flattery while subconsciously dismissing its potential ramifications. Along a rather short way, something that was supposed to be silly turned from something like a paper cut, to a sore which festered, metastasized into an incurable cancer in our relationship, and has now concluded in something akin to a lethal injection.

So? why or how do we lose our way when our able bodies and intelligent minds should easily discern what should be the right (and only) way to go when we?re confronted with simple moral and ethical problems. Why didn?t I coldly and nicely reject a flattering comment from the wrong person? Why did Bill allow the Monica saga to even begin when he of all people knew the ramifications of every misstep from that first smile from her to the bad thoughts of its potential from him? Why do we make comments or take actions we should know before hand that we cannot take back? No one with a sound mind makes a conscious decision to maim himself so why do we do so when it comes to those emotional, or morally and ethically-based situations? Is it the sense that the physical self isn?t injured that we allow things like the potential of losing best friends to happen? We?re the only animals that go where we know there?s potential danger. Is this human condition what separates us from other animals?that we?re of bountiful intelligence to do stupid things? I hope someday I can atone for my inability to protect a friendship from its doom and the pain that we?re all suffering.

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Source: http://madeinaccra.wordpress.com/2012/08/27/losing-a-friend/

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